Fastest way from Rome to Brindisi: Flight, about 1h 15min (from €15). Cheapest: Bus, from €11 (about 7h 25min). Main companies selling this route on 12Go (checked on October 27, 2026): FlixBus, Alitalia, Itabus; main departure point: Rome Tiburtina Bus Station.
There are 2 ways to get from Rome to Brindisi
Select an option below to see the route details and compare prices. Secure booking via our partner 12go.asia.
Companies selling this route on 12Go
Offers listed on 12Go on October 27, 2026 for a departure on November 17, 2026. Timetables and prices change with the date: check them before booking.
| Company | Mode | Departs from | From | Offers |
|---|---|---|---|---|
| FlixBus | Bus | Rome Tiburtina Bus Station | €11 | 5 |
| Itabus | Bus | Rome Tiburtina Largo Mazzoni | €13 | 2 |
| Marino | Bus | Rome Tiburtina | €23 | 2 |
| Alitalia | Flight | Leonardo da Vinci Airport | €136 | 5 |
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Practical tips
Long-distance coaches fill up in summer and around holidays. Reserve your seat online a few days ahead so you keep the lowest fare and avoid paying more at the station on the day.
Rome has several stations, such as Termini and Tiburtina, and coaches do not all leave from the same one. Read your ticket carefully and confirm the exact stop before you head out.
Fares for the flight can be close to the coach when booked ahead. Check both on the same day, then weigh the time saved against the airport transfer and baggage rules.
Bring water, snacks, a light jacket for the air conditioning and a charged phone. Keep valuables and documents with you, and store only your main bag in the hold.
If you fly, allow generous margin to reach the airport and check in, especially at busy times. Rome's airports are well outside the centre, so book your transfer or train in advance.
The journey experience
Getting from Rome to Brindisi is a long hop down to the heel of Italy, and the choice comes down to two clear options: the coach or the plane. There is no need to guess. Compare the duration and price range side by side on this page and you will know in a moment which one suits your trip and your budget.
The coach is the budget-friendly pick for independent travellers who are happy to trade speed for savings. You sit back on a long daytime or overnight run, with room for your luggage in the hold, and you can often sleep or catch up on your notes along the way. It is a sensible choice if you are travelling through Puglia afterwards and want to keep costs low. The flight, by contrast, is the time-saver: a short hop that saves most of a day, ideal if your days in Puglia are limited, and fares can be surprisingly low when you book ahead.
My advice: if time matters more than money, fly; if you are flexible and watching your budget, take the coach and book your seat early in high season. Whichever you choose, check the exact departure point before you go, since Rome has several stations and an airport that is well outside the centre. Once you have picked, book online for instant confirmation and you can travel with peace of mind.
Frequently asked questions — Rome → Brindisi
The coach starts from €11 and typically goes up to €18, which makes it the cheapest way to reach Brindisi. The flight starts from €15 and typically goes up to €41. Booking ahead usually gives the best fares, particularly in high season, so compare both options for your travel date.
The coach takes roughly 7 to 8 hours, so plan for a long day or an overnight run. The flight is much faster, at about 1 hour 15 minutes in the air. Remember to add time for getting to the airport and checking in when you compare the two.
It depends on your priorities. The flight is best if you want to save most of a day, with fares from €15. The coach is the better pick if you want the lowest price, from €11, and do not mind a long ride. Both can be booked online.
Long-distance coaches in Rome usually leave from one of the main stations, such as Termini or Tiburtina, but it depends on the operator and the time. Always check the departure stop shown on your booking confirmation before you travel.
Fly if your time in Puglia is short and you want to arrive quickly, as the flight takes about 1 hour 15 minutes. Take the coach if you want to spend less, with fares from €11, and are happy with a journey of 7 to 8 hours.
Why visit Brindisi?
- ✓ Walk the Lungomare Regina Margherita and watch the sunset over the Adriatic harbour
- ✓ Climb the Roman Columns of Brindisi, marking the end of the ancient Appian Way
- ✓ Visit the Swabian Castle (Castello Svevo) and the imposing Aragonese Castle on the island in the harbour
- ✓ Admire the 12th-century mosaic floor of the Church of San Giovanni al Sepolcro
- ✓ Take a day trip to the white-washed town of Ostuni or the beaches of Torre Guaceto nature reserve
When to visit Brindisi?
MEDITERRANEAN CLIMATE
May to June and September — warm, sunny weather, pleasant sea temperatures and fewer crowds than in July-August
What to do in Brindisi?
Local experiences, must-see sights and activities selected for you
How long to visit Brindisi?
Brindisi deserves 1 to 2 days: spend a day on the historic centre, the Roman column marking the end of the Appian Way, the Swabian Castle and the waterfront, and add a second day for the archaeological museum and a beach stop. Most travellers use it as a base or ferry gateway to Greece, so plan one night to avoid rushing. For a longer stay, use it as a base for day trips to Lecce, Ostuni, Alberobello or Otranto, easily reached by train or car.
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